DnaK-Dependent Accelerated Evolutionary Rate in Prokaryotes
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چکیده
منابع مشابه
DnaK-Dependent Accelerated Evolutionary Rate in Prokaryotes
Many proteins depend on an interaction with molecular chaperones in order to fold into a functional tertiary structure. Previous studies showed that protein interaction with the GroEL/GroES chaperonine and Hsp90 chaperone can buffer the impact of slightly deleterious mutations in the protein sequence. This capacity of GroEL/GroES to prevent protein misfolding has been shown to accelerate the ev...
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Many proteins require the assistance of molecular chaperones in order to fold efficiently. Chaperones are known to mask the effects of mutations that induce misfolding because they can compensate for the deficiency in spontaneous folding. One of the best studied chaperones is the eubacterial GroEL/GroES system. In Escherichia coli, three classes of proteins have been distinguished based on thei...
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ژورنال
عنوان ژورنال: Genome Biology and Evolution
سال: 2016
ISSN: 1759-6653
DOI: 10.1093/gbe/evw102